Abstract:【Abstract】Objective To study the correlation between serum levels of interleukin6 (IL6), interleukin17 (IL17) and soluble intercellular adhesion factor1 (sICAM1) and detection results of Helicobacter pylori (Hp) in patients with coronary heart disease (CHD) and analyze the possible mechanism. Methods A total of 74 patients with CHD admitted to the hospital from January 2016 to January 2019 were enrolled in the study. The relationship between Hp infection and lesion count and plaque nature was observed. The levels of serum IL6, IL17 and sICAM1 were compared among CHD patients with positive Hp or negative Hp. Results The Hp infection rate of patients with coronary heart disease was significantly higher than that of healthy control group (P＜005). The arterial stenosis count and carotid plaque nature were significantly different from those in ealthy control group (P＜005). The levels of serum IL6, IL17 and sICAM1 were significantly higher than those in healthy control group (P＜005). With the increase of stenosis count, the Hp positive rate in patients with coronary heart disease was increased significantly (P＜005), and the levels of serum IL6, IL17 and sICAM1 were also increased in turn (P＜005). The Hp positive rate in patients with coronary artery disease with carotid plaque was significantly higher than that of patients without plaque (P＜005). The Hp positive rate in unstable plaque was significantly higher than that in stable plaque (P＜005). The levels of serum IL6, IL17 and sICAM1 in patients with no plaque, stable plaque and unstable plaque were increased in turn (P＜005). The levels of serum IL6, IL17 and sICAM1 in Hp positive group were significantly higher than those in Hp negative group (P＜005). Conclusion HP infection may participate in the process of CHD by aggravating the inflammatory reaction, which is closely related to the number of artery stenosis and plaque stability.
