【Abstract】Objective To investigate the effect and mechanism of miR1275 targeting Insulin like growth factor 1 receptor(IGF1R) on the proliferation and apoptosis of Nasopharyngeal carcinoma cells. Methods The targeting relationship between miR1275 and IGF1R was predicted by online bioinformatics software and verified by double luciferase reporter gene experiment. Western blotting was used to detect the expression of IGF1R in HONE1 cells transfected with miR1275 mimics or miR1275 inhibitor. MTT, flow cytometry and Western blotting were used to detect the effects of miR1275/ IGF1R axis on HONE1 cell proliferation, apoptosis and expression of protein kinase B(tAKT), Phosphorylated protein kinase B(pAKT), Proliferating cell nuclear antigen(PCNA) and cleaved caspase 3. Results The expression of miR1275 was significantly increased after miR1275 mimics were transfected into HONE1 cells, the cell proliferation activity was significantly decreased, the apoptosis rate was significantly increased, the expression of pAKT and PCNA was significantly decreased, and the expression of cleaved caspase 3 was significantly increased (P＜005). miR1275 can target IGF1R and down regulate its expression. Inhibition of IGF1R expression can significantly reduce the proliferation of HONE1 cells, promote cell apoptosis, down regulate pAKT and PCNA, up regulate the expression of cleaved cysteinyl aspartate specific proteinase 3(cleaved caspase 3) (P＜005), while inhibition of miR1275 and IGF1R expression can reverse the effects of IGF1R on cell proliferation, apoptosis and the expression of pAKT, PCNA and cleaved caspase 3. Conclusion miR1275 can promote the proliferation and inhibit the apoptosis of NPC cells by up regulating the expression of IGF1R.