Abstract:【Abstract】 Objective To study on the correlation between the expression of B7-H3, LIP and MHC-Ⅱ and complicated infection in patients with SAP. Methods 80 patients with SAP treated in our hospital from June 2016 to June 2019 were selected as the study group, and the healthy persons treated in our physical examination center at the same time were selected as the control group (100 cases). The expression levels of each factor in different groups were compared. The sensitivity and specificity of individual and combined detection were evaluated. The risk factors of infection were by logistic regression analysis. Results The expression levels of B7-H3, lip and MHC-Ⅱ were significantly different among the three groups. The highest expression level was found in the infection group, followed by the non infection group and the control group (P＜0.05). The positive rates of serum B7-H3, lip, MHC-Ⅱ, WBC count, percentage of neutrophils, procalcitonin, C-reactive protein and Apache Ⅱ scores in the infection group were significantly higher than those in the non infection group (all P＜0.05). Logistic regression analysis showed that B7-H3, lip, MHC-Ⅱ and Apache Ⅱ scores were independent risk factors of SAP patients complicated with infection. The best cut-off values of B7-H3, lip and MHC-Ⅱ in the diagnosis of SAP complicated with infection were 136.46 pg/mL, 254.34 U/L and 74.23%, respectively. The area under ROC curve was 0.825 (95% CI: 0.766～0.873), 0.786 (95% CI: 0.719～0.823), 0.865 (95% CI: 0.815～0.903). Conclusion B7-H3, lip and MHC-Ⅱ were all highly expressed in serum of SAP patients, which were independent risk factors of SAP patients complicated with infection. They had high diagnostic efficiency of infection and could be used as biomarkers for the diagnosis of SAP patients complicated with infection.
