【Abstract】 Objective To explore the clinical efficacy of complete laparoscopic pericardial devascularization combined with splenectomy in the treatment of cirrhotic portal hypertension (CPH). Methods 140 CPH patients admitted between June 2016 and October 2019 were included as study subjects and divided into observation group and control group, according to the random number table method, with 70 cases in each group. Observation group was given complete laparoscopic pericardial devascularization combined with splenectomy, and control group was given open pericardial devascularization combined with splenectomy. The perioperative status (intraoperative blood loss, operative time, postoperative ambulation time, postoperative hospital stay) were compared between the two groups. The liver function ［alanine aminotransferase (ALT), aspartate aminotransferase (AST)］ was evaluated before operation and at 1 w after operation, and the serum inflammatory factors ［C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin6 (IL-6)］ were evaluated before operation and at 1 d and 1 w after operation. The incidence rate of postoperative complications was recorded in the two groups at 3 months of followup, and the longterm followup results were observed at 1 year after operation. Results Compared with control group, the intraoperative blood loss was less (P＜0.05), and the operative time was longer (P＜0.05), and the postoperative ambulation and postoperative hospital stay were shorter (P＜0.05) in observation group. At 1w after operation, the ALT and AST in the two groups were lower than those before operation (P＜0.05), and there were no significant differences between observation group and control group (P＞0.05). Before operation and at 1 d and 1w after operation, the levels of CRP, TNF-α and IL-6 in the two groups was first increased and then decreased (P＜0.05), and the levels of CRP, TNF-α and IL-6 in observation group were lower than those in control group at 1 d after operation and at 1 w after operation (P＜0.05). The incidence rate of complications in observation group was lower than that in control group (P＜0.05). There were no significant differences in the recurrent digestive bleeding rate and mortality rate between the two groups (P＞0.05). Conclusion Complete laparoscopic pericardial devascularization combined with splenectomy is beneficial to improve perioperative conditions, reduce serum inflammatory factors levels and incidence rate of postoperative complications.