【Abstract】 Objective To study the curative efficacy of carprostol combined with misoprostolin treatment dangerous postpartum hemorrhage of placenta previa. Methods 50 patients with dangerous placenta previa admitted to our hospital from March 2018 to March 2019 were included in this study. They were divided into observation group (n=26) and control group (n=24) according to the simple random number table method. The control group was treated with misoprostol, and the observation group was treated with carboprostol on the basis of the control group. The clinical efficacy, postpartum blood loss, oxidative stress ［superoxide dismutase (SOD), lipid peroxide (LPO), glutathione peroxidase (GSH -P)］, the stress hormone ［norepinephrine (NE) and epinephrine (E) and cortisol (Cor)］ level changes and the occurrence of adverse reactions were observed. Results After treatment, the total effective rate of the two groups was 96.15% and 75.00%, respectively, with significant difference (P＜0.05). The blood loss in the observation group was significantly lower in the control group at 2h postpartum, 8h postpartum and 24h postpartum (P＜0.05). Before treatment, there was no significant difference in the levels of oxidative stress between the two groups. After treatment, SOD and gsh-p levels in the two groups increased significantly, and both the observation group were higher than the control group, LPO significantly decreased, and the observation group was lower than the control group (P＜0.05). Before treatment, there was no significant difference in stress hormone levels between the two groups. After treatment, the levels of NE, E and Cor were significantly increased in both groups, and were significantly lower in the observation group than in the control group (P＜0.05). The total incidence of adverse reactions in the two groups was 11.54% and 25.00%, with no statistically significant difference(P＞0.05). Conclusion Hemabate combined with misoprostol is effective and safe in the treatment of dangerous placenta previa postpartum hemorrhage.