【Abstract】 Objective To study the effect of laparoscopic myomectomy on sex hormones and endocrine status in patients with uterine leiomyoma. Methods 85 cases of hysteromyoma treated in our hospital from January 2018 to January 2019 were analyzed. According to the operation mode, they were divided into observation group (n=43) and control group (n=42). The control group was treated with open myomectomy, and the observation group was treated with laparoscopic myomectomy. The operation, serum progesterone (P), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), myoglobin (myo) and ischemic modified albumin (IMA) were compared between the two groups. Results The operation time of the observation group was significantly higher than that of the control group, and the bleeding volume, anal exhaust time, time of getting out of bed and hospitalization time were significantly lower than those of the control group (P＜0.05). Before treatment, there was no significant difference in the levels of P and E2 in the two groups. After treatment, the levels of P and E2 in the two groups were significantly improved, and the above indicators in the observation group were lower than those in the control group (P＜0.05). Before treatment, the level of LH in the two groups was significantly lower than that in the control group (P＜0.05). After treatment, the level of LH and FSH in the two groups increased significantly, but the above indexes in the observation group were lower than those in the control group (P＜0.05). Before treatment, the level of myo and IMA in the two groups had no significant difference. After treatment, the level of myo and IMA in the two groups increased significantly, but the above indexes in the observation group were lower than those in the control group (P＜0.05). The total incidence of complications in the two groups was 4.65%, 19.05 %. The difference was statistically significant (P＜0.05). Conclusion Laparoscopic myomectomy is effective in the treatment of hysteromyoma, which can effectively improve the level of sex hormone and endocrine, and has fewer complications.