Objective To explore the effect of dopamine combined with dobutamine in the adjuvant treatment of severe pneumonia in children and the effect of inflammatory factors.Methods 120 children with severe pneumonia admitted to the hospital from February 2018 to February 2020 were selected as the subjects. They were divided into control group (n=60) and observation group (n=60) by the random number method. The control group was given routine treatment, and the observation group was given adjuvant therapy with dopamine and dobutamine on the basis of the control group. The clinical efficacy, remission time of symptoms and signs, pediatric critical illness score (PICS), C-reactive protein (CRP), tumor necrosis factorleukinbeam, interleukin-6 (il-6), and the incidence of adverse reactions were compared between the two groups. Results The effective rate of treatment in the observation group was higher than that in the control group (P＜0.05). The respiratory recovery time, heart rate recovery time, fever relief time, cyanosis relief time, disappearance time of lung rales, hemogram recovery time and hospital stay of the observation group were shorter than those of the control group (P＜0.05). After treatment, serum PCT, DD, BNP, CRP, TNFPCR, and IL6 levels in the observation group were lower than those in the control group, and PICS scores, PaO2 and SpO2 levels were higher than those in the control group (P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). ConclusionAdjuvant therapy with dopamine and dobutamine is effective in treating children with severe pneumonia. It can relieve clinical symptoms, improve signs and blood gas indexes, and reduce serum PCT levels and inflammatory cytokines, with high safety.