肥胖高血压患者左室构型特点及危险因素的Logistic回归分析
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国家自然科学基金(81803892,81774111);上海市科学技术委员会科研计划项目(19401970400)


Logistic regression analysis of left ventricular geometric characteristics and risk factors in obese hypertensive patients
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    摘要:

    目的 探讨中心性肥胖合并高血压患者左室构型的特点及影响因素,为防治肥胖相关性高血压的心脏损害提供思路。方法 本研究采用横断面流行病学调查方法,共纳入2015年5月~2016年2月我院心内科门诊及住院的227例中心性肥胖合并高血压病患者。采集患者一般资料、炎症因子、早期肾脏损害指标、尿酸、B型钠尿肽(BNP)、心脏超声等。根据心脏超声特点将患者分为正常构型、向心性重构、离心性肥厚、向心性肥厚四组,采用非条件Logistic回归分析影响左室构型紊乱发生的危险因素。结果 227例患者中,正常构型58例(25.55%),向心性重构99例(43.61%),向心性肥厚44例(19.38%),离心性肥厚26例(11.45%);其中左室构型紊乱者高达74.45%,以向心性重构为主。经非条件Logistic回归分析,超敏C反应蛋白(hsCRP)水平升高(OR=1.591,95%CI=1.185~2.073)、血压分级升高(OR=1.611,95%CI=1.008~2.575)、BNP升高(OR=1.408,95%CI=1.064~1.863)、年龄增长(OR=1.524,95%CI=1.054~2.203)增加了中心性肥胖合并高血压患者发生左室构型紊乱的风险。结论 ①中心性肥胖合并高血压患者左室构型紊乱者高达74.45%,以向心性重构为主。②中心性肥胖合并高血压患者,随着hsCRP、年龄、BNP和血压等级升高,发生左室构型紊乱的风险也增加。

    Abstract:

    Objective To explore the characters and influencing factors of abnormal left ventricular geometry in patients with central obesity and hypertension and provide ideas for the prevention and treatment of heart damage in obesityrelated hypertension.Methods 227 patients with central obesity complicated with hypertension from May 2015 to February 2016 in our hospital were enrolled. The general data, inflammatory factors, early renal damage index, uric acid, B-type natriuretic peptide (BNP), cardiac ultrasound were collected. According to the characteristics of echocardiography, the patients were divided normal configuration, concentric remodeling, centrifugal hypertrophy and concentric hypertrophy. The risk factors of left ventricular geometric disorder were analyzed by unconditional logistic regression.ResultsAmong 227 patients, 58 (25.55%) had normal configuration, 99 (43.61%) had centripetal remodeling, 44 (19.38%) had concentric hypertrophy and 26 (11.45%) had eccentric hypertrophy. Among them, 74.45% of them had left ventricular remodeling disorder. Unconditional logistic regression analysis showed that the level of high sensitivity C-reactive protein (hsccrp) increased (R=1.591, 95% CI=1.185~2.073), blood pressureclassification increased(OR=1.611, 95%CI=1.008~2.575), BNP increased (OR=1.408, 95%CI=1.064~1.863), age increased (OR=1524, 95%CI=1.185~2.073), blood pressure classification increased (OR=1.611, 95% CI=1.008~2575), BNP increased (OR=1.408, 95%CI=1.064~1.863), age (OR=1.524, 95%C=1.064~1.863), age (OR=1.524, 95%CI=1.524, 95% CI=1.524, 95%CI=1.054~2.203) increased the center The risk of left ventricular geometry disorder in obese patients with hypertension.Conclusion 74.45% of patients with central obesity complicated with hypertensionhad left ventricular remodeling. With the increase of hsCRP, age, BNP and blood pressure grade, the risk of left ventricular geometry disorder is also increased in patients with central obesity and hypertension. 

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  • 在线发布日期: 2020-12-28
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