Objective To observe the clinical effectiveness and safety of tissue engineered artificial ceramic bone combined with plateletrich plasma in the treatment of early femoral head necrosis, providing a new idea and direction for head and hip therapy. Methods 70 early osteonecrosis of the femoral head patients included in this study were randomly divided into test group (35 cases) and control group (35 cases), according to the digital table method. The test group was treated with tissueengineered artificial ceramic bone combined with autologous plateletrich plasma for bone grafting. The control group was treated with artificial ceramic bone compression and bone grafting. The general information, Harris score, hip pain VAS score and imaging data of the two groups of patients were recorded before and after treatment. Results The Harris score of hip joint function of the two groups of patients before surgery was not statistically significant (P>0.05). The Harris score of hip joint function of the test group was 12 months after surgery compared with the control group. The difference was statistically significant (P<0.05). The hip pain VAS scores of the two groups of patients before surgery were not statistically significant (P>0.05), and the hip pain of the experimental group was significantly reduced 12 months after surgery, compared with the control group. There was a significant difference (P<0.05). Xrays, CT, and MRI examinations of the experimental group at 6 and 12 months after surgery showed implanted ceramic bone and neonatal bone growth tendency, and the imaging data showed no further progress of femoral head necrosis. In the control group, the implanted ceramic bone was seen, but no obvious new bone growth was observed. Although the imaging data did not show further progress of femoral head necrosis, MRI showed a high T2 signal in the femoral head.Conclusion Ceramic bone compression and bone grafting combined with plateletrich plasma can effectively improve the symptoms of patients, delay the time of femoral head collapse, and provide a new method and new idea for the treatment of head protection for the treatment of early osteonecrosis of the femoral head.