Objective To explore the diagnostic value of routine noninvasive indicators for esophageal varices (EV) in patients with liver cirrhosis. Methods 221 patients with cirrhosis admitted to the department of gastroenterology at the second affiliated hospital of Zhengzhou university from August 2015 to September 2019 and underwent electronic gastroscopy were selected. All patients were divided into no or light EV group (83 cases) and moderate or severe EV group (138 cases), according to the results of electronic gastroscopy. The results of blood routine examination, liver function, coagulation function, color Doppler ultrasound and other examinations were collected to investigate the diagnostic value of EV in liver cirrhosis.Results There were significant differences in portal vein diameter, PLT, AST, ALB, PT, PTA, APRI score and ascites between the two groups (P＜0.05). Binary Logistic regression analysis showed that the portal vein diameter (OR=2.007, P＜0.001), ALB (OR=0.931 P=0.01), and APRI score (OR=2.189,P＜0.001) were statistically significant. ROC curve results showed that the AUC of portal vein diameter, APRI score and ALB were 0.789, 0.797 and 0.346 respectively. Drawing the ROC curve of the portal vein diameter + APRI score showed that the AUC was 0.874.Conclusion The portal vein diameter combined with APRI score has higher diagnostic value for moderate and severe EV in liver cirrhosis. It may have better diagnostic value for moderate and severe EV caused by hepatitis cirrhosis.