Objective To investigate the changes of serum prealbumin (PA), cholinesterase (CHE) and alphafetoprotein (AFP) levels in patients with liver cirrhosis complicated with portal hypertension before and after interventional therapy and their clinical significance. Methods 202 patients with liver cirrhosis and portal hypertension underwent interventional therapy and 200 healthy subjects received physical examination in West China Hospital of Sichuan University from February 2017 to December 2018 were selected as the research subjects, and they were included in the livercirrhosisgroup and the control group, respectively. Serum PA, CHE and AFP levels and liver function indicators such as total bilirubin (TBIL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in both groups were detected before and after treatment. The predictive value of serum PA, CHE and AFP levels for the prognosis was analyzed. Results Compared with the control group, serum PA and CHE were lower, and AFP was higher in the liver cirrhosis group (P＜0.05). After treatment, liver function indexes such as TBIL, ALT and AST in the liver cirrhosis group were significantly reduced (P＜0.05), serum PA and CHE levels were increased, and AFP was decreased (P＜0.05). Pearson correlation analysis showed that serum PA and CHE were negatively correlated with liver function indexes such as TBIL, ALT and AST (P＜0.05), and serum AFP was positively correlated with liver function indexes (P＜0.05). The levels of PA and CHE in ineffective patients were significantly lower than those in the effective patients, and the AFP was significantly higher than that in the effective patients. The difference was statistically significant (P＜0.05). The area under the curve of treatment effect was 0.831, 0.820, 0.791, and the Jordanian index was the highest when the cutoff values were 9261 mg/L, 2.97 kU /L, 7.44 μg/L. Taking 1 year after operation as the end point of follow-up,the allcause mortality rate of the liver cirrhosis group was 2574%. The serum PA and CHE levels in the death group were significantly lower than those in the survival group, and the AFP was significantly higher than that in the survival group before and after operation (P＜0.05). Logistic multivariate analysis showed that after correction of other factors, preoperative serum PA, CHE, and AFP levels were independent factors affecting prognosis in patients with portal hypertension of cirrhosis.Conclusion Patients with liver cirrhosis and portal hypertension have decreased serum PA and CHE and elevated AFP. After interventional therapy, all indicators are improved significantly. The indicators can be used to predict the prognosis, thus providing reference for the followup treatment after interventional operation.