Objective To explore treatment of immune function of rheumatoid arthritis (RA) patients by methotrexate combined with meloxicam and influences on levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF). Methods180 RA patients admitted to the hospital from January 2016 to September 2018 were enrolled. They were randomly divided into control group and observation group by simple random sampling, 90 cases in each group. The control group was treated with methotrexate. On this basis, observation group was additionally treated with meloxicam. The curative effect and immune function, and changes in levels of serum ESR, CPR, CCP and RF were compared between the two groups. Results The total response rate of observation group was higher than that of control group (95.56% vs 86.67%) (P＜0.05). The morning stiffness time of observation group was shorter than that of control group, number of joint swelling and joint tenderness was less than that of control group, joint pain was milder than that of control group, and DAS28 score was lower than that of controlgroup (P＜0.05). After treatment, level of differentiation cluster 8 (CD8+) in both groups was increased, while levels of differentiation cluster 4 (CD4+), CD4+/CD8+, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) decreased (P＜0.05). After treatment, levels of ESR, CRP, CCP antibody and RF in observation group were lower than those in control group (P＜0.05).Conclusion The curative effect of methotrexate combined with meloxicam is good on RA, with high safety.