Sepsis induced disseminated intravascular coagulation is one of the important complications that threaten the lives of patients. Early diagnosis will have a huge impact on subsequent treatment and the prognosis of patients. Since 2001, International Society of Thrombosis and Haemostasis has successively issued multiple editions of disseminated intravascular coagulation guidelines, and issued a separate diagnostic management process for sepsisinduced disseminated intravascular coagulation in 2019. Compared with foreign guidelines, the 2017 domestic guidelines have different focuses.In order to raise domestic scholars’attention to sepsis related coagulation disorders and diffuse intravascular coagulation,and promote scientific research and clinical thinking, this article interprets "International Thrombosis and Hemostasis Association (ISTH) Guidelines Recommendations: Sepsisrelated coagulation dysfunction and diffuse intravascular coagulation (2019)”.