【Abstract】Objective To explore the effect of quality control cycle (QCC) activity on patients received sedation and analgesia in emergency intensive care unit (EICU). Methods A singlecenter retrospective study method was used to continuously enroll 183 patients needed sedation and analgesia from the EICU of West China Hospital of Sichuan University. The patients who did not receive the QCC management were included as a control group (88 cases) from January 1, 2018 to July 14, 2018, and routine care was carried out. From July 15th, 2018 to December 31st, 2018, the patients was selected as a QCC group (95 cases), and QCC activities were carried out on the basis of routine care. Patients in both groups were evaluated by criticalcare pain observation tool (CPOT), Richmond agitation sedation scale (RASS) and Glasgow coma scale (GCS). At the same time, information on age, weight, disease type and other data were collected and compared.Results The scores of CPOT, RASS and GCS in the QCC group were significantly lower than those in the control group (P＜005). Sedative and analgesic effects in the QCC group were greater(P＜005). The completeness of scale filling, consistency of scoring results, sedative and analgesic normality and achievement rate of objectives in the quality control group were all higher than those in the control group (P＜005). The allcause mortality rate of the patients in QCC group during 28 days was lower than that of the control group (P＜005). There was no statistically significant difference in age, weight, disease type, etc. between the two groups of patients (P＞005). Conclusion QCC activities in emergency and intensive care unit can not only improve the achievement rate of sedation and analgesia goals, but also improve the integrity of sedation and analgesia scale, the consistency and standardization of sedation and analgesia score results, and the comprehensive ability of mastering and applying sedation and analgesia related knowledge. Strengthening sedation and analgesia management can improve the survival rate of patients with severe EICU, which can be widely used in clinical practice.