【Abstract】Objective To study and analysis of the incidence ofRLS in CS patients,who were young and middleaged people and analyze the correlation between the two and the difference of the detection rate of RLS between the two methods. Methods 170 young and middle-aged patients with CS who came to our department from January 2017 to October 2018 were selected as the experimental group, and 54 healthy volunteers were selected as the control group. The results of TTE and C TCD were used to diagnose RLS, and the difference of RLS detection rate between the two groups was compared.Results In the experimental group, the total positive rates of C TCD and TTE in diagnosing RLS were 606% and 476%, respectively. In the control group, the total positive rates of C TCD and TTE in diagnosing RLS were 241% and 185%. The total positive rate of RLS diagnosed by C TCD in the experimental group was significantly higher than that in the control group (P＜005). The total positive rate of TTE in diagnosing RLS was significantly higher than that in the control group (P＜005). In the experimental group, the positive rate of RLS diagnosed by C TCD was significantly higher than that by TTE (P＜005). Conclusion There is a correlation between cryptogenic stroke and RLS, which should be paid more attention in clinical practice. C TCD has a higher detection rate in the diagnosis of RLS, which can be used as the first choice for cryptogenic stroke.