Abstract:【Abstract】Objective To explore the application value of coronary CTA prospective scanning combined with low tube voltage, contrast flow rate and total iodine dosage in coronary artery disease screening. Methods 86 volunteers met the standard were randomly divided into retrospective multiphase scanning group (Traditional group, 46 cases) and prospective single phase scanning group (Prospective group, 40 cases). In the traditional group, Iodophor (370 mgI/ ml) was used as the contrast agent, and in the prospective group, Temeran (400 mgI / ml) was used as the contrast agent. Taking the BMI=25kg/m2 as the limit, the voltage of 80kV (BMI>25kg/m2, <28kg/m2) and 70kv (BMI<25kg/m2) tubes were used respectively, and four different schemes of fixed contrast agent dosage and flow rate were adopted. Objective image quality was compared by CT value and contrast noise ratio (CNR); subjective image quality was compared based on Likert grading scoring method, and the difference of population composition ratio and effective radiation dose between the two groups were analyzed. 〖WTHZ〗Results〖WTBZ〗〓There was no significant difference in objective image quality between the two groups. The subjective image quality score of the prospective group was lower than that of the traditional group, and there was one case of scanning failure, but the overall image quality could meet the diagnosis requirements, and the sensitivity of the diagnosis results of the two groups was similar. In the prospective group, the dose of radiation was lower, the dose of contrast medium was less, and the flow rate was slower. Conclusion Prospective single phase scan based on the prospective group has the risk of scanning failure, but on the premise of ensuring the reliability of the equipment, the heart rate of the subject<80bpm and BMI<28kg/m2. The scope of CCTA examination can be extended to the routine physical examination, providing strong support for clinical prevention.