【Abstract】Objective To study the effect of oxcarbazepine combined with topiramate on cognitive recovery in patients with epilepsy after stroke. Methods 80 patients with poststroke epilepsy treated in our hospital from June 2017 to June 2018 were divided into combined treatment group and control group according to complete random method, 40 cases in each group. Patients in the combined treatment group were treated with oxcarbazepine and topiramate, while patients in the control group were treated with topiramate. Insulinlike growth factor1 (IGF1), post neuron specific enolase (NSE), central nerve specific protein β (S100β), epileptic discharge and the number of involved leads were measured before and after the treatment in the two groups. MMSE, MOCA and ADL were performed. The therapeutic effect and the incidence of adverse reactions were counted.Results After treatment, the levels of IGF1 in the combined treatment group were higher than those in the control group, while the levels of NSE and S100β were lower than those in the control group (P＜005). The scores of MMSE, MOCA and ADL in the combined treatment group were higher than those in the control group (P＜005). The leads of epileptic discharge and involvement in the combined treatment group were lower than those in the control group after treatment. (P＜005). After treatment, the total effective rate of the combined treatment group was higher than that of the control group (P＜005).Conclusion Oxcarbazepine combined with topiramate in the treatment of poststroke epilepsy can promote the recovery of cognitive function, reduce the number of epileptic seizures, and improve the daily living ability and quality of life of patients with significant effect.