【Abstract】Objective To investigate and analyze the distribution of dyslipidemia and its influencing factors before and after the management of chronic diseases in 2014 and 2015 in Shunqing District, Nanchong. Methods Totally 23598 and 24300 residents aged 45 and over were recruited from the Shunqing District of Nanchong City in 2014 and 2015. Data was collected through questionnaire, physical examination, biochemical examination and dietary survey, and the health management of chronic disease was carried out simultaneously. Statistical analysis was performed using chisquare, ttest, variance analysis, and logistic regression analysis. Results The prevalence of dyslipidemia were 457% vs 294% in 2014 and 2015, respectively. The awareness rates were 72% vs 110% and the treatment rates were 23% vs 43%, respectively. Univariate analysis in 2014 showed that dyslipidemia was associated with gender, education, smoking, drinking, family history of dyslipidemia, hypertension, diabetes mellitus, exercise, body mass index and so on. Logistic analysis in 2014 showed that gender, educational level, smoking, family history of dyslipidemia, hypertension, diabetes mellitus, exercise and body mass index were independent factors of dyslipidemia. Univariate analysis in 2015 showed that dyslipidemia was associated with gender, educational level, hypertension, diabetes mellitus and body mass index. Logistic analysis in 2015 showed that gender, educational level, hypertension, diabetes mellitus, coronary heart disease, animal oil consumption, body mass index and other independent factors were related to dyslipidemia. Conclusion The dyslipidemia situation of the population aged 45 and over in Nanchong is still grim. Gender, education level, smoking history, dyslipidemia family history, hypertension, diabetes mellitus, body mass index are independent related factors of 〖JP2〗dyslipidemia in Nanchong city. The health management of blood lipid in Nanchong area is effective but needs further refinement.