【Abstract】Objective To investigate the expression of circular RNA_circFNDC3B in normal epidermal melanoma cells and malignant melanoma cells and explore the effects of circFNDC3B on migration and invasion of A2058 cells. Methods The expression of circFNDC3B and in malignant melanoma cells and normal epidermal melanoma cells was evaluated by realtime quantitative polymerase chain reaction (RTQPCR). Small interfering RNAs (siRNAs) were used to knockdown the expression of circFNDC3B in A2058 cells. Migrative distance of A2058 cells transfected with siNC or sicircFNDC3B was measured by wound healing assays. Invasive ability of A2058 cells transfected with siNC or sicircFNDC3B was measured by transwell assays. Expression of Ecadherin and Ncadherin in A2058 cells transfected with siNC or sicircFNDC3B was measure by western blot. Expression of microRNAs (miRNAs) in A2058 cells transfected with siNC or sicircFNDC3B was measure by RTQPCR. Results CircFNDC3B was abnormally higher in malignant melanoma cells than that in epidermal melanocytes HEMaLP cells. Silencing the expression of circFNDC3B in A2058 cells resulted in significantly decreased abilities of cell migration and invasion (P＜005). The expression of Ecadherin which was the epithelial cells marker was enhanced. The expression of Ncadherin which was the mesenchymal cells marker was suppressed. miR147 expression which was an established tumor suppressive miRNA was upregulated. Conclusion CircFNDC3B is upregulated in malignant melanoma cells, and promotes cell migration and invasion of A2058 cells and epithelialmesenchymal transition (EMT) via inhibiting miR147 expression. 