Objective To detect the level of long noncoding RNA (LncRNA) p53 dependent apoptosis regulator (TP73AS1) in diffuse large Bcell lymphoma (DLBCL) and to explore its relationships with clinicopathological characteristics and prognosis. Methods From January 2010 to March 2014, 109 patients with DLBCL in West China Hospital of Sichuan University were selected as the study objects (DLBCL group), and 110 patients with lymphoproliferative disease were selected as the controls (control group), the expression level of LncRNA TP73AS1 was detected by realtime fluorescence quantitative analysis (qRTPCR). Its relationships with patients' gender, age, location of disease, Ann Arbor stage, bone marrow invasion, ECoG physical condition score, systemic (B) symptoms, international prognostic index (IPI) score, lactate dehydrogenase (LDH) level and histological morphology, Kaplan Meier survival curve was used to analyze the effect of LncRNA TP73AS1 on the survival of patients with DLBCL, and COX was used to analyzed the prognostic factors in patients with DLBCL. Results Compared with the control group, the level of LncRNA TP73AS1 in DLBCL group increased (P＜0.05). Compared with the low expression group of LncRNA TP73AS1, the age (≥60), site (intranodal), Ann Arbor stage (Ⅲ  Ⅳ), ECOG score (＞1), B symptom (yes), IPI score (medium and high risk), LDH (abnormal) in the high expression group increased (P ＜ 0.05), and the survival rate decreased (P＜0.05). High expression of LncRNA TP73AS1, Ann Arbor stage (Ⅲ Ⅳ), ECOG score (＞1 point), B symptom (yes) were independent risk factors for poor prognosis in patients with BLBCL. Conclusion The level of LncRNA TP73AS1 in DLBCL is increased, high expression of LncRNA TP73AS1 is closely related to poor prognosis, LncRNA TP73AS1 can be used as a potential marker to predict the poor prognosis of DLBCL.