Objective To observe the curative effect of insulin aspart 30 combined with metformin and liraglutide in the treatment of obese type 2 diabetes mellitus (T2DM) with poor glycemic control and the influence on insulin function and sex hormones.Methods A total of 70 patients with poor glycemic control and obese T2DM who were admitted to the hospital from January to December 2018 were selected. They were divided into observation group and control group by the random number table method, with 35 cases in each group. The control group was treated with insulin aspart 30 and metformin. On this basis, observation group were additionally treated with liraglutide. Both groups were continuously treated for 12 weeks. Fasting plasma glucose (FPG), postprandial 2hour plasma glucose (2hPG), glycosylated hemoglobin (HbA1c), height, weight, total cholesterol (TC), triglyceride (TG), highdensity lipoprotein (HDL) and lowdensity lipoprotein (LDL) in both groups were measured before and after treatment. The contents of testosterone (T), estradiol (E2) and sex hormonebinding globulin (SHBG) in male patients, levels of estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) in female patients at one week after the end of menstruation were determined. The incidence rates of hypoglycemic events in the two groups were statistically analyzed. Results After treatment, FPG, 2hPG and HbA1c in observation group were significantly lower than those in control group and those before treatment (P＜0.05). The weight, BMI, TC, TG and LDL of observation group were significantly lower than those of control group and those before treatment (P＜0.05). HDL levels in both groups were decreased after treatment (P＞0.05). The levels of T SHBG and E2 in males in observation group were significantly higher than those in control group and those before treatment (P＜0.05). The E2 and LH in females in observation group were significantly higher than those in control group and those before treatment (P＜0.05). There was no statistically significant difference in the incidence of hypoglycemic events between the two groups.Conclusion The application of insulin aspart 30 combined with metformin and liraglutide in treatment of obese T2DM with poor glycemic control can effectively reduce blood glucose level, improve insulin function, correct lipid metabolism disorder and upregulate levels of sex hormones.