Objective To study the mechanism of Amomum kravanh on doxorubicininduced nephropathy in rats and its relationship with the expression of STAT1p53p21 signaling pathway. Methods A total of 120 male SD rats were randomly divided into normal control group, model control group, Amomum kravanh low dose group, Amomum kravanh medium dose group, Amomum kravanh high dose group and benazepril group. A doxorubicin nephropathy model was constructed by a single tail vein injection of 10 mg/kg doxorubicin. The drug was administered on the fourth day after modeling, and the rats in the low, medium and high doses of Amomum kravanh were intragastrically administered with 15, 30, 45 g/kg white soybean. Rats in the benazepril group were intragastrically administered with 10 mg/kg benazepril daily. The rats in the model control group and the normal control group were given the same amount of normal saline once a day for four weeks. The amount of PRO, BLO, BIL in the urine is detected by a urine analyzer. The levels of TC, TG, TP, ALB, BUN, and Scr in the serum of rats were detected by an automatic biochemical analyzer. Renal tissue damage was observed by HE staining. Renal cell apoptosis is detected by flowmetry. The expression of caspase3, Bax, Bcl2, STAT1, p53 and p21 was detected by Western blot. The content of SOD and MDA is detected by a kit, Serum levels of inflammatory factors IL1β, IL6 and TNFα were measured by ELISA. Results Rats in each group fed the drug compared with the model control group. The contents of PRO, BLO and BIL in urine and the contents of TC, TG, BUN and Scr in blood were all reduced to varying degrees. The levels of TP and ALB in the blood increased to varying degrees. Glomerular disorders are all reduced to varying degrees. Renal cell apoptosis rate, caspase3 and Bax protein expression levels were all reduced to varying degrees. The expression level of Bcl2 protein increased to varying degrees. MDA content and IL1, IL6 and TNFα levels were reduced to varying degrees. SOD activity has increased to varying degrees. The expression levels of STAT1, P53 and P21 protein were all decreased to some extent. The white bean meal medium dose group has the most significant effect. Conclusion Amomum kravanh alleviates rat adriamycin nephropathy by regulating STAT1P53P21 signaling pathway.