Objective This study aims to compare the repair ability of concentrated growth factors (CGF) and advancedplatelet rich fibrin (A-PRF) on regeneration of immediateimplant soft tissue defect and to provide guidance for oral clinical implantation treatment. Methods A-PRF and CGF membranes were prepared by specific centrifuge equipment and filmpressing instruments for further tissue section staining and scanning electron microscope observation. Four adult healthy male beagle dogs were enrolled in the experiment. Six selected teeth were extracted under anesthesia for immediate implant surgery, which were divided into three groups by halfmouth random control method: APRF group, CGF group and blank group. After regularly prepared implant holes, implants (3.8*7mm) were implanted and freshly prepared CGF or A-PRF membranes were put on the corresponding sites. The implants were directly implanted in the blank group without any additive. After full reduction, the wound was sutured tightly without tension. One week and one month after operation, the soft tissue healing condition was recorded. Beagle dogs were sacrificed after one month. Immunohistochemical staining was performed to explore soft tissue nerve and vessel regeneration. Results A-PRF's fibrin network structure is looser than that of CGF. The soft tissue healing of A-PRF group and CGF group was better than that of blank group, while A-PRF group performed best. Conclusion A-PRF has a better effect on promoting soft tissue regeneration than CGF. 