【Abstract】 Objective To investigate the efficacy of intensitymodulated radiotherapy (IMRT) combined with concurrent taxel +cisplatin (TP) regimen in the treatment of inoperable stage Ⅲ nonsmall cell lung cancer (NSCLC). Methods The clinical data of 194 patients with stage Ⅲ NSCLC in our hospital from January 2013 to April 2016 were retrospectively analyzed. According to the treatment regimens, they were divided into traditional concurrent chemoradiotherapy group (traditional group, 61 cases), simple IMRT group (IMRT group, 66 cases) and IMRT combined with concurrent TP chemotherapy regimen group (observation group, 67 cases). The shortterm clinical efficacy, occurrence of adverse reactions and quality of life ［Karnofsky physical fitness status (KPS) score, Spitzer Quality of Life Index (QLI)］ before radiotherapy and at 3 months after radiotherapy were recorded in the three groups. KaplanMeier method was used to draw the 3year survival curves, and Logrank method was used to compare the 3year survival rates among the three groups. Results There was no statistically significant difference in the shortterm clinical efficacy between IMRT group and traditional group (P＞0.05), and was lower than that in observation group (P＜0.05). There were no significant differences in the occurrence of leukopenia and radiation esophagitis among the three groups (P＞0.05). There was no significant difference in the occurrence of radiation pneumonia between observation group and IMRT group (P＞0.05), but the incidence rate of radiation pneumonia in traditional group was higher than that in observation group and IMRT group (P＜0.05). After Logrank test, it was found that there was no significant difference in the 3year survival rate between IMRT group and traditional group (P＞0.05), and was lower than that in observation group (P＜0.05). Conclusion IMRT combined with concurrent TP in the treatment of stage Ⅲ NSCLC has significant effects and less adverse reactions, and it can improve the longterm survival rate of patients and has high clinical application value.