【Abstract】 Objective To compare the therapeutic effect of radiotherapy combined with endocrine therapy on advanced prostate cancer. Methods 110 patients from the department of oncology, 986 hospital of PLA air force from December 2016 to May 2018 were randomly divided into the endocrine therapy group (control group) and the combined treatment group (observation group) with 55 patients, respectively. The observation group received endocrine therapy during or after radiotherapy, while the control group received endocrine therapy only. The level of prostatespecific antigen (PSA) remission, the rate of bone pain remission, and the incidence of adverse events before and after treatment were compared. Results After treatment, the remission rates of PSA in the observation group and the control group were 72.7% and 58.2%, respectively, and the difference was statistically significant (P＜0.05). The bone pain in both the observation group and the control group was relieved to different degrees. The bone pain relief rate in the observation group (93.3%) was better than that in the control group (75.0%), and the difference was statistically significant (P＜0.05). Observation group of patients with bone marrow suppression was slightly higher than the control group. The incidence of bone marrow suppression and Ⅰ～Ⅱ degrees difference between the two groups was statistically significant (P＜0。05). The observation group and control group Ⅰ ～Ⅱ vomiting in patients with gastrointestinal reaction rate were 127% and 164%, respectively, The incidence of gastrointestinal reaction observation group was lower than that in the control group, but there was no statistically significant difference in the two groups (P＞0。05).〖WTHZ〗Conclusion Radiotherapy combined with endocrine therapy for patients with advanced recurrent prostate cancer achieved a better clinical efficacy with a high rate of PSA and bone pain relief, and a low incidence of gastrointestinal adverse reactions to improve a better quality of life.