Objective To explore the application value of ultrasoundguided nerve block combined with general anesthesia in the treatment of acromioclavicular joint dislocation. Methods 28 patients with acromioclavicular dislocation were randomly divided into observation group (ultrasoundguided nerve block combined with general anesthesia) and control group (general anesthesia). Mean arterial pressure (MAP), heart rate (HR), cortisol and angiotensin II were used to evaluate hemodynamic changes and stress response perioperatively. The time period of operation, anesthesia, extubation and resuscitation, the dosage of anesthetic drugs, postoperative pain and sedation scores and the incidence of side effects were used to evaluate the anesthesia effect. Results Compared with the control group, the observation group has lower level of MAP and HR during the time of incision and intubation, less cortisol and angiotensin II after extubation and 24 hours after operation, the lower dosage of propofol and sufentanil, lower VAS score and sedation score after operation. The incidence of dizziness, nausea and vomiting was significantly smaller in observation group than that in control group (P＜0.05).Conclusion Ultrasound guided nerve block combined with general anesthesia has great value in the treatment of acromioclavicular joint dislocation. It can significantly reduce the stress response, maintain stable vital signs during the operation, lower the dosage of drugs for anesthesia and pain, it also has fewer side effects, which means it is worthy of clinical application.