Objective To study the effect of prolonging the interval of GnRHa administration on the clinical efficacy of treating endometriosis patients. Methods From September 2017 to September 2018, 114 patients treated with endometriosis at the First People's Hospital of Liangshan Yi Autonomous Prefecture and the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected as the survey subjects, and randomly divided into routine group and extended group. Each of the 57 patients was treated with triptorelin. The interval between the conventional group was 4 weeks and that between the extended group was 6 weeks. The dysmenorrhea, uterine volume, serum sex hormone levels, menstrual recovery time, total effective rate, and complications and recurrence of the two groups of patients were compared before and after treatment. Results The dysmenorrhea and uterine volume of the patients in the extension group were significantly better than those in the conventional group (P＜0.05). The levels of LH, FSH, and E2 in the two groups were significantly reduced after treatment, but there were no significant differences in the two indicators between the two groups (P＞0.05). The menstrual recovery time of patients in the extension group was significantly better than that in the conventional group (P＜0.05). The total effective rates of treatment in the extension group and the conventional group were 8947% and 9123%, respectively, and there was no significant difference between the two groups (P＞0.05). The incidence of various complications in patients was significantly lower than that in the conventional group (P＜0.05). After one year follow-up, there was no significant difference in recurrence between the two groups (P＞0.05).Conclusion Patients with endometriosis should be treated with Gn RHa for extended interval intervals. On the basis of ensuring effective treatment, they can further alleviate dysmenorrhea and reduce uterine size, reduce serum sex hormone levels, extend the period of menstrual recovery and reduce the occurrence of complications.