Objective To investigate the effects of lowdose tripterigium wilfordii glycosides (TWG) in the treatment of chronic glomerulonephritis (CGN) and the influence on inflammatory factors and renal hemodynamics. 〖WTHZ〗Methods〖WTBZ〗 74 patients with CGN admitted to the hospital from May 2017 to May 2018 were divided into the observation group and the control group by the random number table method, 37 patients in each group. The control group was only given routine treatment, and the observation group was treated with lowdose TWG (05mg/kg) for 5 months. The urine protein (Pro), serum creatinine (Scr) and blood urea nitrogen (Bun) were detected to compare the renal function between the two groups. The changes of glomerular filtration function in the two groups were evaluated by glomerular filtration rate (GFR) and endogenous creatinine clearance rate (Csr). The levels of serum interleukin-6 (IL-6) and tumor necrosis factorα (TNFα) in both groups were detected to compare changes of serum inflammatory factors between the two groups before and after treatment. Color Doppler ultrasound was used to determine renal artery blood flow parameters before and after treatment, including peak systolic flow velocity (PSFV), enddiastolic flow velocity (EDFV), pulsatility index (PI) and resistance index (RI) to evaluate renal hemodynamic changes before and after treatment. Results The levels of Pro, Scr and Bun in observation group after treatment were lower than those before treatment and those in the control group (P＜0.05). After treatment, GFR and Csr in the observation group were higher than those before treatment and those in the control group (P＜0.05). Levels of serum IL6 and TNFα in the observation group after treatment were significantly lower than those in the control group and those before treatment (P＜0.05). The PSFV and EDFV in observation group after treatment were higher than those in the control group and those before treatment (P＜0.05). However, PI and RI were lower than those in the control group and those before treatment (P＜0.05). The responserate of the observation group was significantly higher than that of the control group (83.78% vs 64.86%) (P＜0.05). Conclusion Lowdose TWG can effectively reduce urinary Pro, improve renal function, inhibit the levels of inflammatory factors such as IL-6 and TNFα, enhance ERPF and reduce RVR, which provides a reference for the treatment of CGN.