帕拉米韦治疗急诊非重症流行性感冒的临床价值
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四川省卫生厅科研课题(120282)


Clinical value of peramivir in the treatment of nonsevere acute influenza patients
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    摘要:

    目的 探讨帕拉米韦氯化钠注射液治疗急诊非重症流行性感冒的临床价值。方法 选取2018年1月~2018年12月我院收治的265例急诊非重症流行性感冒患者为研究对象,按照数字表法随机分为对照组(n=132)和观察组(n=133)。对照组患者采用疏风解毒胶囊等治疗,观察组患者给予帕拉米韦氯化钠注射液等治疗,两组疗程均为1周。对比两组患者治疗3、7天后发热、咳嗽、咽痛、头痛等缓解、消失的情况,比较两组临床疗效,记录进展为重症患者的情况及不良反应。结果 治疗3、7天后,观察组发热、咳嗽、咽痛、头痛等缓解、消失的情况明显优于对照组(均P<0.05);观察组总有效率(92.48%)明显高于对照组(8485%)(P<0.05);观察组进展为重症患者率(0%)明显低于对照组(2.3%)(P<0.05);两组均未有不良反应患者。结论 帕拉米韦治疗急诊非重症流行性感冒的临床疗效显著,可减少并发症,降低重症患者率,且安全无不良反应,可在临床推广应用。

    Abstract:

    Objective To investigate the clinical value and adverse reactions of peramivir sodium chloride injection in the treatment of emergency nonsevere influenza.Methods Two hundred and sixtyfive cases of severe acute influenza were diagnosed and treated in isolation. According to the numerical table method, 132 patients in the control group were randomly divided into the observation group and 133 patients in the observation group. The course of treatment is one week. After 3 days and 1 week of treatment, the data changes of fever, cough, pharyngeal pain and headache in the two groups were compared, and the clinical efficacy was observed. Results After 3 and 7 days of treatment, fever, cough, sore throat and headache in the observation group were relieved and disappeared better than those in the control group (P<0.05). The total effective rate of the observation group (92.48%) was significantly higher than that of the control group (84.85%) (P<0.05). The rate of severe patients in the observation group (0%) was significantly lower than that in the control group (2.3%)(P<0.05). There were no adverse reactions in both groups.Conclusion The efficacy of pramivir in the treatment of emergency non severe influenza is significant, it can reduce complications, reduce the rate of severe patients, and can be widely used in clinical practice.

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  • 在线发布日期: 2020-08-17
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