Objective To study application value of sodium polyglucosamine carboxylate in pulmonary lobectomy.Methods 115 patients with lobectomy admitted to our hospital from February 2016 to March 2018 were randomly divided into observation group (n=60) and control group (n=55). The control group was given normal saline to wash the thoracic cavity. The group was washed with medical sodium glucosamine carboxylate before the chest was closed, and the two groups of patients continued to have analgesia for 48 hours. The perioperative conditions, visual analog pain score (VAS), serum inflammatory factors, postoperative recovery, and postoperative complications were compared between the two groups. Results The drainage volume and blood loss of thoracic tube in the observation group were less than those in the control group 3 days after operation, and the extubation time and hospitalization time in the observation group were shorter than those in the control group. The fever lasted for more than 48 hours and the healing of surgical incision in the observation group were better than those in the control group(P＜0.05). The VAS scores of T1 (2h), T2 (12h), T3 (24h) and T4 (48h) were lower in the postoperative observation group than in the control group(P＜0.05). The level of serum inflammatory factor white blood cell count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) levels in the observation group was significantly lower than that of the control group(P＜0.05). The recovery time of anal exhaust and the amount of gastrointestinal decompression in the observation group were less than those in the control group(P＜0.05). There were no obvious complications such as atelectasis, respiratory failure, pneumonia and residual lung necrosis during treatment in both groups. Conclusion The sodium polyglucosamine carboxylate has bactericidal and antiinflammatory effects in pulmonary lobectomy, reducing blood loss, improving the healing of patients after operation and shortening hospital stay, which is worthy of promotion in clinical application.