Abstract:Objective To investigate the clinical value of Kanglaite injection combined with FOLFOX4 regimen in the treatment of advanced colorectal cancer.Methods 60 patients with advanced colorectal cancer who were treated in Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 2016 to December 2017 were enrolled. The patients were randomly divided into control group (only give FOLFOX4 singleagent therapy) and treatment group (give Kanglaite injection combined with FOLFOX4 therapy). After two cycles of chemotherapy, the differences of clinical efficacy indicators and adverse reactions were compared between the two groups.Results The short-term clinical effective rate of the control group (20.00%) was lower than that of the observation group (46.67%), but the difference was not statistically significant (P>0.05), while the clinical benefit rate of the observation group (83.33%) was significantly higher than that of the control group (60.00%), the difference was statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the observation group were higher than those in the control group (P<0.05), while the levels of CD8+ in the two groups were lower than those before treatment, but the level of CD8+ cells in the observation group was significantly higher than that in the control group (P<0.05). Karnofsky score and QOL score of the two groups were significantly higher than those before treatment, VAS score was significantly lower, and the improvement degree of the observation group was higher than that of the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, the decrease of leukocytes and neutrophils, the impairment of liver function and diarrhea were significantly lower than those in the control group (P<0.05). Conclusion Kanglaite injection combined with FOLFOX4 can not only increase the clinical benefit rate, obviously improve the levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in patients with advanced colorectal cancer, improve the immune function of the body, but also improve the physical condition and quality of life of patients, relieve pain and reduce the incidence of adverse reactions, which can be widely used in clinical practice.
