【Abstract】Objective To investigate the clinical applications of goaldirected fluid therapy for pancreatoduodenectomy and observe the effect of goald directed fluid therapy and Conventional liquid therapy on intestinal function in patients undergoing laparoscopic pancreaticoduodenectomy. Methods 60 patients undergoing pancreatoduodenectomy under general anesthesia were randomly divided into groups G and groups C. Goaldirected fluid therapy was used in Group G, whereas conventional fluid therapy was used in group C. Liquid management, dosages of vasoactive drugs, operation time, urine volume, blood loss, number of cases of concentrated red blood cell input, tracheal extubation time and hospital stay were recorded. Mean arterial pressure（MAP）, heart rate（HR）, cardiac index（CI）, central venous pressure（CVP）, stroke volume variation（SVV）, lactic acid（Lac） and Central venous oxygen saturation（Scv02） of patients were recorded before anesthesia (T0), at the beginning of operation (T1), at the time of specimen excision (T2), and at the end of operation (T3). Choose seven time points，such as T0T3 and 1, 2 and 3 days (T4, T5, T6) after operation. Central venous blood was drawn and diamine Oxidase, (DAO), DLactic and lipopolysaccharide (LPS) were detected. Neurotrophin3(NT3) and galanin(GAL) were detected at the time T0T3. Results Compared with group C at T2 to T3, the MAP increased, CVP decreased, SVV decreased, CI increased, low Lac, high ScvO2（P＜005）. The amount of crystalloid requirements and total infusion in group G were less than that of group C (P＜005). The colloidal solution and dopamine usage in group G were fewer than that of group C (P＜005). The extubation time of tracheal intubation in group G was earlier than that in group C. The plasma DAO, Dlactic acid and LPS in group G were lower than those in group C at the time T2T6. The peak of DAO, Dlactic acid and LPS appeared on the first day after operation, and then began to decrease. Comparing with T0, NT3 went up at T1~T2 and decreases at T3. The change of G group was more obvious than that of C group. However, plasma GAL increased continuously at T2 and T3. Similarly, the changes in group G were more obvious than those in group C. Conclusion Goaldirected fluid therapy can maintain effective circulating blood volume and blood pressure, and can guarantee tissue perfusion. Goaldirected fluid therapy can improve microcirculation and protect intestinal mucosal barrier function and motor function.