Objective To explore the relationship between the severity of diabetic foot ulcer (Wagner grade: 1 5) and uric acid level in patients with type 2 diabetes. Methods A retrospective study was conducted on 134 hospitalized Type 2 diabetic patients with diabetic foot ulcer (DFU) attended our hospital from January 2017 to May 2018, According to serum acid levels ? the patients were divided into high uric acid (HUA) group and normal uric acid (NUA) group. The differences in general data and clinical indicators between the two groups and logistic regression were used to analyze the influencing factors of hyperuricemia in DFU patients. The DFU patients with Wagnerl (Wl) , 2 (W2) and 3 (W3) were divided into a group, Wagner 4 and 5 into another group (W4). We analyzed the clinical characteristics and uric acid levels between the four groups ? and to investigate the correlation between the severity of foot ulcer lesions and uric acid levels of the 4 groups. Results Compared with the NUA group, the Wagner grade of the patients in the HUA group was higher (P<0. 05) , while the smoking rate, the course of diabetes, WBC and creatinine of the patients in the HUA group were higher (P<0. 05), but the glycosylated hemoglobin in the HUA group was lower (P<0.05). The results of binary logistic regression analysis showed that Wagner grade was an independent risk factor for the increase of serum uric acid in diabetic foot combined with Hua Group (P<0, 05). There were statistically significant differences in smoking, course of diabetes, TC, LDL, WBC, RBC, Hb, ALB, CA, UA among W1 W4 groups. P. Wagnefs grade was positively cor related with the course of diabetes? WBC and serum uric acid (P<0. 05), and negatively correlated with RBC, Hb, ALB, TC, LDL and Ca (P<0. 05). After adjustment of multivariate logistic regression analysis, the or value of W2? W3, W4 and blood uric acid increased gradually compared with W1 group (P<0, 05). Conclusion There was a relation ship between the degree of DFU and uric acid in type 2 diabetes, and the foot ulcer was more serious in patients with dia betic foot ulcer combined with hyperuricemia. Meanwhile, the higher the Wagner classification grade for DFU, the higher the serum uric acid is.