Objective To investigate the effects of silencing EGFR on learning and memory ability and apoptosis of hippocampal cells in rats with cerebral hemorrhage. Methods 40 SD healthy male rats were selected. 10 rats were randomly selected as the normal group. The other 30 rats were divided into silence group, model group and control group. In normal group and model group, 8 p 1 PBS was injected into the lateral ventricle, 8 p 1 CAV vector was injected. into the lateral ventricle of control group ? and 8 卩 1 EGFR siRNA lentivirus expression vector was injected into the lateral, ventricle of silence group. The ability of learning and memory of rats in each group was tested. The proliferation of hipp ocampal cells in each group was detected by MTT. The apoptosis of hippocampal cells in each group was detected by flow cytometry. The relative expression of bcl 2, Bax and caspase 3 was detected by Western blot. Results The escape latency of silent group was longer than that of normal group, shorter than that of model group and control group. The number of times of crossing platform was lower than that of normal group ? higher than that of model group and control group (P<0. 05). The proliferation rate of hippocampal cells in silent group was lower than that in normal group at each time point, higher than that in model group and control group (P<0. 05). The apoptotic rate of hippocampus cells in silent group was higher than that in normal group, lower than that in model group and control group (P<0.05), The relative exp res sion of Bcl 2 and Caspase 3 in silent group was lower than that in normal group, higher than that in model group and con trol group, and the relative expression of Bax in silent group was higher than that in normal group, lower than that in model group and control group (P<0.05). Conclusion Silencing EGFR can improve the learning and memory ability of rats with cerebral hemorrhage, regulate the relative expression of apoptosis related proteins? B.cl 2, Bax and caspase 3., so as to promote the proliferation of hippocampal cells in rats with cerebral hemorrhage and inhibit the apoptosis of hipp ocampal cells in rats with cerebral hemorrhage.