【Abstract】 Objective To investigate the value of individualized nursing management during perioperative period in daytime operation of vocal cord polypectomy. Methods 168 patients with vocal cord polypectomy during the otolaryngology department of West China Hospital of Sichuan University from February to August in 2018 were retrospectively analyzed. Patients were divided into control group and observation group according to different nursing service methods, with 84 cases in each group. The control group received routine nursing services and followup, and the observation group performed individualized quality nursing services on this basis. Compare the effects of different types of nursing services on perioperative patients. The preoperative conditions and postoperative medication compliance, pain and anxiety, postoperative wound bleeding, postoperative infection, eating status, and nursing satisfaction scores were compared between the two groups. Results The preoperative preparation of the patients in the observation group was better than that of the control group, and the time spent was small, and the anxiety of the patients was significantly different from that of the observation group (P＜0.05). The patient′s medical compliance was higher than that of the control group (P＜0.05). There was significant difference in postoperative pain between the two groups (P＜0.05). The number of postoperative wound hemorrhage and infection in the observation group was less than that in the control group (P＜0.05). The observation group had excellent postoperative feeding. In the control group (P＜0.05), the nursing satisfaction score observation group was superior to the control group (P＜0.05). Conclusion Individualized quality nursing service can improve the preoperative preparation efficiency and reduce the preoperative anxiety of patients during the perioperative period of vocal cord polypectomy. It can improve the patient′s postoperative medication compliance, reduce postoperative pain and anxiety, and reduce postoperative operation. Wound infection and bleeding, improve sound status, and improve care satisfaction can provide a reference for clinical care.