【Abstract】 Objective To observe the diagnostic value of combined detection with serum Mtype phospholipase A2 receptor 1 (PLA2R1) and immunoglobulin G (IgG) in idiopathic membranous nephropathy (IMN). Methods 96 patients with nephrotic syndrome admitted to the hospital were enrolled, including 52 IMN patients, 24 patients with secondary membranous nephropathy (SMN) and 20 patients with atypical membranous nephropathy (AMN). They were included in IMN group, SMN group and AMN group, respectively. The general clinical data and laboratory indexes ［albumin (ALB), serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipid Protein cholesterol (LDL-C), serum creatinine (Scr), glomerular filtration rate (eGFR), 24h urine protein quantitation, serum PLA2R1, IgG］ were compared among the 3 groups. The diagnostic sensitivity and specificity of serum PLA2R1 and IgG for IMN were analyzed. Results The serum PLA2R1 was the highest in IMN group, followed by AMN group and SMN group (P＜0.05). The serum IgG level of IMN group was significantly higher than that of SMN group (P＜0.05). ROC curve analysis showed that the diagnostic sensitivity, specificity and AUC of serum PLA2R1 for IMN were 77.36%, 89.85% and 0.801, respectively. The above indexes of serum IgG were 60.37%, 71.25% and 0.713, respectively. And above indexes of their combination diagnosis were 80.14%, 93.78% and 0.912, respectively. Conclusion Serum PLA2R1 and IgG combination detection can improve diagnostic sensitivity and specificity for IMN, which helps to identify IMN, AMN and SMN clinically.