【Abstract】 Objective To investigate the gastrointestinal symptoms and malnutrition in uremic hemodialysis patients with cardiac insufficiency and its influencing factors. Methods From March 2017 to August 2018, 100 patients with uremic hemodialysis and cardiac insufficiency were divided into gastrointestinal symptoms group (76 cases), nongastrointestinal symptoms group (24 cases), malnutrition group 511 cases) and nonmalnutrition group (49 cases). Relevant blood biochemical indicators were tested in each group. General and clinical data of patients were collected by retrospective analysis. The influencing factors of gastrointestinal symptoms and malnutrition in uremic hemodialysis patients with cardiac insufficiency were analyzed by multivariate logistic regression analysis. Results Among 100 uremic hemodialysis patients with cardiac insufficiency, 76 (76.00%) had gastrointestinal symptoms and 24(24.00%) had no gastrointestinal symptoms. The main symptoms were dyspepsia syndrome (48.00%). 51 (51.00%) were malnutrition patients and 49 (49.00%) were nonmalnutrition patients. The results of univariate regression analysis showed that whether there were gastrointestinal symptoms in uremic hemodialysis patients with cardiac dysfunction, and the sex, age, body mass index (BMI), age, hemoglobin (HB) level, total cholesterol (TC), parathyroid hormone (PTH), hematocrit (HCT), administration. The number of tablets, history of glucocorticoid use, dialysis time, kt / V level of residual kidney and diabetes mellitus were related. Multivariate logistic regression analysis showed that female patients, high thyroid hormone level and diabetes mellitus were independent risk factors for gastrointestinal symptoms in uremic hemodialysis patients with cardiac insufficiency（P＜0.05）, while longterm dialysis, high serum CRP level, low serum ALB level, low urea clearance index and high age were independent risk factors for uremic hemodialysis. Independent risk factors for malnutrition in patients with cardiac insufficiency （P＜0.05）. Conclusion Sex, parathyroid hormone level, the number of tablets, glucocorticoid use history, dialysis time, kt / V level of residual kidney and diabetes mellitus are the main influencing factors of gastrointestinal symptoms in uremic hemodialysis patients with cardiac insufficiency. High age, long time dialysis, low urea clearance index and high serum CRP level are the main influencing factors of malnutrition in uremic hemodialysis patients with cardiac insufficiency.