【Abstract】 Objective To explore the early intervention measures for patients with high risk of deep vein thrombosis after pelvic surgery. Methods From January 2018 to March 2019, 143 patients with high risk of deep vein thrombosis (DVT) in pelvic surgery were selected from Beijing Luhe Hospital Affiliated to Capital Medical University for prospective study. According to the exclusion criteria, 3 patients were excluded and 5 patients dropped out of the experiment. 135 patients were included in the study. Before the study, according to SPSS17.0, they were randomly divided into IPC group (68 cases) and IPC+LMWH group (67 cases). IPC group used basic prevention combined with mechanical prevention; IPC+LMWH group combined or sequential application of antithrombotic pressure pump (IPC)+low molecular weight heparin (LMWH) on the basis of basic prevention. The coagulation indexes and the incidence of DVT were compared between the two groups. Results There was no significant difference between the two groups (P＞0.05), but there was significant difference between the two groups (P＜0.05). There was significant difference in DVT incidence between the two groups (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion IPC+LMWH combined or sequential prevention of gynecological diseases pelvic deep vein thrombosis in highrisk patients with significant effect, can be used in clinical promotion.