【Abstract】 Objective To analysis the cognition, attitude and behavior of home segregation and protection during the breakout of Coronavirus disease (COVID-19) in China. Methods Subjects from 29 provinces were invited to participate in a questionnaire online survey (https://www.wjx.cn/) from Feb 16Feb20,2020. Results A total of 1121 subjects were included in our study. The score of knowledge about COVID19 was （60.59±17.79). There was a significant difference in scores among different age, gender, education level and occupation (P＜0.05). 82.07% of the residents knew the knowledge of home isolation and protection, and the main access was WeChat (78.59%), TV (58.07%) and website (48.8%). 72.7% of the residents hope that the medical workers to provide care guidance, mainly in the form of WeChat (73.86%) and telephone (61.73%). The average score of K10 was (1563±553). There were 969 cases (86.4%) with good psychological state. The difference of different education level was statistically significant (P＜0.05). Conclusion After the outbreak of COVID-19, through the propaganda and guidance of the government and society for home quarantine, most people pay close attention to the epidemic situation, have high awareness of disease. They have a positive attitude, cooperate well with the protective measures taken by the government. Meanwhile, the residents maintain a good psychological state, but there are still a few them who have different problems. The government needs to strengthen publicity and education, and implement individualized guidance, the COVID19 could be promoted without leaving dead ends.