Objective To analyze the related factors of hematoma formation in percutaneous renal biopsy. Methods 448 percutaneous renal biopsies were performed. The age, sex, body mass index (BMI), blood pressure, blood pressure, blood and platelet count, blood urea nitrogen, serum creatinine, plasma albumin, platelet count, tissue strip length and other clinical case parameters were analyzed by continuous and bivariate analysis. The categorical clinicopathologic variables and hematoma were analyzed using univariate logistic regression analysis. Results Age, gender, blood pressure measurement, platelet count, blood urea nitrogen, serum creatinine, plasma albumin, disease type and other parameters were not statistically significant with the formation of hematoma (P＞0.05). There was statistical significance between the length of tissue strips and the presence or absence of hematoma (P＜0.05). Body mass index and hematoma were statistically significant (P＜0.05). The tissue strip length and hematoma were statistically significant (P＜0.05).ConclusionBMI and the tissue strip length was significantly associated with the formation of hematoma in renal biopsy. The longer the tissue strip, the higher the chance of hematoma formation. The greater BMI, the greater the chance of hematoma formation.