Objective To investigate the effect of different doses of Jinzhen oral liquid combined with azithromycin in the treatment of mycoplasma pneumonia in children. Methods 75 hospitalized children were selected from the pediatrics department of Chengdu First People′s Hospital and Nanchong Central Hospital from 2016 to 2018 and divided into double dose group, routine dose group and control group. Azithromycin was given to all three groups as the basic treatment, and the double dose group was given double dose of Jinzhen oral liquid on the basis of the basic treatment, every 20 ml, 2 times a day for 2～3years old children; every 20 ml, 3 times a day for 4～7years old children; every 30 ml, 3 times a day for 4～7years old children. Conventional dose is the half of the double dose. The control group did not take oral Jinzhen oral liquid at all.The total clinical treatment efficiency, clinical recovery time, time of complete antipyretic, time of disappearance of cough or cough phlegm, time of disappearance of rafter sound in lungs, time of absorption of chest film inflammation and incidence of complications were compared in the three groups. Results The total effective rate of the double dose group was higher than that of the conventional dose group and the control group (P＜0.05). The total effective rate of the conventional dose group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The remission time of cough or cough phlegm and the disappearance time of rale in lung in the double dose group were shorter than those in the conventional dose group and the control group (P＜0.05). Compared with the control group, the time of relieving cough or phlegm and the time of disappearance of rale in lung were shorter in the conventional dose group, with statistically significant differences (P＜0.05). There was no statistically significant difference in the time of antipyretic among the three groups (P＞0.05) (all the children with concurrent central infection were those with no antipyretic effect). The inflammatory absorption time of chest film in the double dose group (75±25 days) was shorter than that in the conventional dose group (80±30 days) and the control group (10.5±4.5 days) (P＜0.05). The inflammatory absorption time of chest radiograph in the conventional dose group was shorter than that in the control group (P＜0.05). There was no statistically significant difference in the incidence of complications among the three groups (P＞0.05). There was no recurrence in the double dose group, and there was 1 recurrence in both the conventional dose group and the control group. There was no statistically significant difference in the three groups (P＞0.05).Conclusion Jinzhen oral liquid combined with azithromycin can shorten the course of mycoplasma infection and pneumonia in children. It is worthy of clinical application.