Objective To understand the characteristics and rules of adverse reactions of Corona Virus Disease 2019 (COVID-19) in Nanchong area using lopinavirritonavir, so as to provide evidence for clinical medication safety and effectiveness. Methods COVID-19 cases in 9 hospitals in Nanchong were collected and investigated by retrospective analysis. The main adverse reaction types, different treatment methods, treatment measures and prognosis were collected and analyzed. Results As of February 17, 2020, 35 cases of COVID19 in Nanchong were admitted. Among these, 33 cases were treated with the diagnostic protocol of COVID19. Patients were given lopinavirritonavir 200mg/50mg BID for antiviral therapy. At the same time, other symptoms were treated with symptomatic support. In the course of drug use, 18 patients had different degrees of diarrhea, rash and other adverse drug reactions. There were 11 cases of diarrhea, 3 cases of diarrhea with vomiting, 1 case of diarrhea with rash. The incidence of diarrhea adverse reactions was 45.45%. 〖WTHZ〗ConclusionCOVID-19 in the region has been explored and summarized for nearly a month, and symptomatic supportive therapy is the key of treating COVID19. When COVID19 patients used lopinavir ritonavir appeared adverse reactions such as nausea, vomiting and diarrhea. It is recommended to take measures such as stopping or symptomatic treatment.