【Abstract】 Objective To study the application effects of total laparoscopic Deltashaped anastomosis (Delta-shaped) and laparoscopic assisted Billroth I anastomosis (Billroth I) in the radical operation of distal gastric cancer. Methods A retrospective analysis was performed on 115 patients with radical operation of laparoscopic distal gastric cancer from May 2015 to May 2018 in our hospital. They were divided into Delta-shaped group (33 cases) and Billroth I group (82 cases) according to the surgical procedures. The two groups were given lymph node dissection. Delta-shaped group was given Delta-shaped surgery. Billroth I group was given Billroth I surgery. The intraoperative indexes, tissue specimens and postoperative recovery were observed in the two groups, and the incidence rate of postoperative complications was counted. Results The anastomosis time in the two groups was comparable (P＞0.05), and the initial operation time in Delta-shaped group was longer than that in Billroth I group (P＜0.05). The operative time and intraoperative blood loss after learning curve in Delta-shaped group were shorter than those in Billroth I group (P＜0.05). The tumor size and lymph node dissection quantity were similar in the two groups(P＞0.05), and the incision length and margin distance in Delta-shaped group were lower than those in Billroth I group (P＜0.05). The postoperative analgesia time, the first ventilation time, gastrointestinal function recovery time, ambulation time, suture removal time and hospital stay were shorter in Delta-shaped group than those in Billroth I group (P＜0.05). The incidence rate of postoperative complications was comparable in the two groups(P＞0.05). Conclusion The short-term advantage of Delta-shaped surgery in radical operation of laparoscopic distal gastric cancer is higher than that of Billroth I. Delta-shaped surgery has relatively smaller surgical trauma, faster postoperative recovery, and higher clinical application value.