【Abstract】 Colorectal cancer is one of the common malignant tumors o£ the digestive tract in humans. Due to the complexity o£ molecular mechanisms, it is difficult for cancer researchers to do early diagnosis and treatment in colorectal cancer. In recent years, the role o£ long non-coding RNA (IncRNA) in the development and progression of colorectal cancer has received increasing attention. Cell signaling pathway plays an irreplaceable role in the development, progression and outcome o£ colorectal cancer. As an important component, a large number o£ IncRNAs play a subtle regulatory role. The complexity of colorectal cancer regulation system involves the diversity o£ cell pathways. Single or minority IncRNAs are not enough to have a decisive influence. Controlling IncRNAs from the overall level of the cellular signaling pathway and summarizing them can provide reference for future research directions and translational medicine. This article will review the basic concepts o£ IncRNAs and the research progress o£ IncRNAs-mediated signaling pathways in colorectal cancer.