【Abstract】 Objective To study the effect of partial cystectomy (PC) on serum VEGF and MCP-1 in patients with muscular invasive bladder cancer (MIBC). Methods 92 patients with MIBC admitted to our hospital from October 2011 to June 2013 were selected and divided into PC group (?z=46) and RC group 3=46) according to the random number table method. PC group was treated with PC and RC group with Radical cystectomy (RC). Intraoperative blood loss, operation time and hospitalization time were observed in two groups. Serum levels of VEGF, MCP-1 tumor factors, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX), advanced oxidative protein product (AOPP) and other oxidative stress factors before and 7 days after surgery were detected. Postoperative complications, postoperative recurrence and survival were observed. Results The amount of intraoperative blood loss, operation time and hospital stay in PC group were less than those in RC group (P＜0. 05). Seven days after surgery, there was no difference in serum VEGF and MCP-1 levels between the two groups (P>0. 05). Seven days after surgery, MDA and AOPP levels in the PC group were lower than those in the control group, and GSH-PX, SOD and SOD levels were higher than those in the RC group (P＜0. 05). The incidence of postoperative complications in PC group (6. 51%) was lower than that in RC group (26.09%) (P＜0.05). There was no difference in postoperative recurrence rate and 1, 3 and 5-year survival rate between the two groups (P>0. 05). Conclusion PC can effectively remove the lesion and inhibit the expression of VEGF,MCP-1 in the treatment of MIBC, which can obtain the same curative effect as RC, with less trauma, less influence on the body, and low postoperative complications and recurrence rate.