【Abstract】 Objective To investigate the prevalence of nocturnal hypertension in patients with chronic kidney disease (CKD) by ambulatory blood pressure monitoring (ABPM), and analyze the influencing factors of nocturnal hypertension in CKD patients. Methods From January 2017 to October 2017, 123 CKD patients with hypertension were enrolled in the nephrology department of Nanchong Central Hospital. ABPM was performed with ambulatory blood pressure monitor to understand the prevalence of hypertension at night. According to the results, they were divided into night hypertension group (110 cases) and non night hypertension group (13 cases). Blood glucose, albumin, creatinine, urea nitrogen, uric acid, blood lipid, electrolyte, C-reactive protein, homocysteine, parathyroid hormone and hemoglobin were collected. Color Doppler echocardiography was used to evaluate the changes of heart structure and function, and color Doppler echocardiography was used to evaluate the formation of vascular plaque. Single factor and multiple factor Logistic regression were used to analyze the influencing factors of night time hypertension. Results The prevalence of nocturnal hypertension was 89.43%, and the prevalence of simple nocturnal hypertension was 29.27%. Compared with non nocturnal hypertension group, urea nitrogen, creatinine, uric acid, homocysteine, parathyroid hormone, potassium and phosphorus in blood were significantly increased, GFR, albumin and hemoglobin were significantly decreased in nocturnal hypertension group (P＜0.05). Logistc regression analysis showed that there was a significant correlation betweennocturnal hypertension and age, GFR, albumin, creatinine, homocysteine (P＜0.05). Conclusion The prevalence of nocturnal hypertension was 89.43%. Age, GFR, albumin, creatinine and homocysteine were the influencing factors of nocturnal hypertension.