高原地区部队营区腺病毒流行特征及发病特点
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西藏自治区自然科学基金项目


Characteristics of adenovirus prevalence and incidence in military barracks in plateau area
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    【摘要】 目的 探讨高原地区部队营区腺病毒流行特征、发病特点。 方法 收集西藏军区总医院收治的2016年11月~2018年2月以呼吸道疾病起病的698例部队患者,收集咽拭子进行腺病毒荧光定量PCR检测并分型,观察发病比例。并对腺病毒患者季节分布、人群特点等流行病学特点及临床症状、治疗方案进行归纳分析。最后对急性发病期部队营区内500例无急性呼吸道疾病症状人员进行抽样检测腺病毒隐匿性感染情况。 结果 腺病毒感染占以急性呼吸道疾病起病患者的50.7%(354/698),其中55型占92.6%,发病主要集中在12、1、2月份(85.0%),18~22岁年龄组发病人数最多(82.7%),战士占853%,干部占147%。发病主要表现为发热(39.1±0.8℃)、咳嗽(96.3%)、咽痛(95.2%)、肌肉酸痛乏力(64.1%),实验室检查发现白细胞以正常[(4~10)×109/L]或升高(>10×109/L)为主, CT示肺部病变多为下肺野渗出性。接受抗病毒及对症治疗后皆好转。500例无症状人员中,隐匿性腺病毒概率为10.0%。结论 近两年来高原地区部队营区急性呼吸道传染病以腺病毒55型为主,起病急,传染性强,好发于冬季,以青年战士为主,给予抗病毒及对症治疗后,皆治愈,为控制部队腺病毒疫情提供了依据。

    Abstract:

    【Abstract】 Objective To explore the characteristics of adenovirus prevalence and incidence in military barracks in plateau area. Methods 698 army patients with respiratory diseases from November 2016 to February 2018 were collected from the General Hospital of Tibet Military Region. Pharyngeal swabs were collected for detection and typing of adenovirus by fluorescence quantitative PCR. The incidence rate was observed. The epidemiological characteristics of adenovirus patients, such as seasonal distribution, population characteristics, clinical symptoms and treatment programs were analyzed. The occult infection of adenovirus was detected in 500 persons without symptoms of acute respiratory diseases in the military barracks during the acute period. Results Adenovirus infection accounted for 50.7% (354 / 698) of the patients with acute respiratory diseases, of which 55 type accounted for 92.6%. The incidence was mainly in December, January and February (85.0%). The incidence was the highest in the 1822yearold group (82.7%). Soldiers accounted for 853% and cadres 14.7%. The main symptoms were fever (39.1±0.8 ℃), cough (96.3%), pharyngeal pain (95.2%), muscle ache and weakness (64.1%). Laboratory examination showed that the leukocytes were mainly normal [(4~10)×109/L] or increased (>10×109/L). CT showed that the lung lesions were mostly exudative in the lower lung field. After receiving antiviral treatment and symptomatic treatment, they all improved. Among 500 asymptomatic patients, the probability of hiding gonad virus was 10.0%. Conclusion In the past two years, the acute respiratory infectious diseases in the military barracks in the highland area were mainly adenovirus type 55, which had an acute onset and strong infectivity. It was prone to occur in winter, mainly in young soldiers. After being given antiviral and symptomatic treatment, they were all cured, providing basis for the control of the adenovirus epidemic in the army.

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  • 在线发布日期: 2020-02-13
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