Objective To investigate the effect of Whole course nutrition management model based on ERAS concept on patients with pancreaticoduodenectomy. Methods 108 patients underwent PD in JanuaryDecember 2016 were used as a control group for traditional nutritional support. 144 patients underwent PD from January to February 20, 2017 were used as observation groups to provide full nutrition. The management model included setting up a fullscale nutrition management team, establishing a fullscale nutrition management process, and formulating detailed preand post nutrition nutrition support programs according to the nutrition screeningnutrition assessmentnutrition intervention principle, and making a medical history acquisition board. The postoperative rapid recovery index and albumin level were compared between the two groups. Results The mean time to start EN, recovery time of bowel sounds, time of anal exhaust, length of hospitalization day, and hospitalization cost of the observation group were shorter than those of the control group (P＜0.05). The albumin value was higher than that of the control group on the 10th day after surgery (P＜0.05). There was no significant difference in postoperative complications between the two groups at the time of admission and 1 day before surgery (P＞0.05). Conclusion The whole process of nutrition management based on ERAS can effectively promote the recovery of intestinal function after PD, shorten the hospitalization day, reduce the hospitalization cost, and improve the postoperative albumin level.