Objective To explore effects of notoginsenoside R1 on cardiac function, lung tissue injury and immune imbalance in rats with traumatic shock. Methods 45 SD rats were randomly divided into control group, model group, high, medium and lowdose notoginsenoside R1 treatment group. Model group and treatment groups were given closed fracture of upper middle femur and femoral artery bloodletting to establish rat models of traumatic shock, while control group was only treated with trauma and no shock. The rats in each group were resuscitated with normal saline. The treatment groups were treated with 50, 100 and 200 mg/kg notoginsenoside R1 for intragastric administration (once/d, continuous intragastric administration for 7d). The control group and model group were intragastrically administered with an equal volume of normal saline. The cardiac function was compared among all groups. The expression levels of serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB), Mb (myoglobin) and inflammatory factors in each group were analyzed by ELISA kit. The pathological injury of lung tissues was analyzed by HE staining and lung tissue wet/dry ratio. The levels of ERK1/2, pERK1/2, p65 and pp65 in lung tissues were analyzed by western blot.Results MAP, HR and LVSP, and level of serum IL-10 in notoginsenoside R1 treatment group were significantly increased, while levels of serum Mb, cTcI, CK-MB, TNF, IL-1β and iNOS, and lung tissue wet/dry ratio were significantly decreased (P＜0.05). The pathological results showed that lung tissue injury was significantly improved. Westernblot results showed that expression ratio of ERK1/2/pERK1/2 and expression level of pp65 in rat lung tissues were significantly decreased (P＜0.05), and they showed significant decreases in dosedependence (P＜0.05). Conclusion Highdose notoginsenoside R1 can improve cardiac function and lung function injury in rats caused by traumatic shock by blocking ERK1/2 and NF-kB signaling pathways, and regulate expression levels of inflammatory factors.