Chest compression is the cornerstone of cardiopulmonary resuscitation. In recent years, cardiopulmonary resuscitation guidelines have highlighted the importance of highquality chest compression. A large number of studies have confirmed that in addition to the adequate compression depth, rate, reduction of the compression interruption, and adequate recoil, the structural mechanical properties of the thoracic cage, and the dynamic characteristics of the chest compression also have a significant impact on the compression quality. Paying attention to the effects of the above factors during the chest compression and perform the personalized compression protocol can improve the quality of the chest compression. This review provided a brief summary and comment on the improvement of above research fields and the future prospective.